Category:2008 British novels
Category:2008 children's books
Category:Historical novels
Category:Novels set in the 14th century
Category:Novels set in the 15th century
Category:Novels set in the Wars of the Roses
Category:Novels by Bernard CornwellOpioids in the treatment of chronic pain.
The endogenous opioid peptides (endorphins, enkephalins and dynorphins) have an important role in pain modulation and analgesia. They inhibit pain by directly activating opioid receptors in the spinal cord and brain stem, and are modulated by the endogenous opioid peptide (enkephalin) system. They also inhibit the release of numerous neurotransmitters, in particular serotonin, norepinephrine and substance P. This results in peripheral analgesia and the reduction of inflammation, as well as a decrease in sensory input and potential pain facilitation. The direct and indirect analgesic effects of opioids are well established, with a wide variety of clinical uses for the treatment of chronic pain. However, opioids have been responsible for numerous and often severe side effects. The most serious of these are respiratory depression, nausea and vomiting, sedation, and dependence and tolerance on chronic use. There have been reports of opioid-induced constipation, pruritus, urinary retention and even seizures, but they are most often minor. The long-term use of opioids for chronic pain is associated with the development of tolerance and, in some cases, dependence.// GENERATED FILE - DO NOT EDIT.
// Generated by gen_vcl_endian.py using Matlab version: 7.12.
static const uint8_t _matlab_quotient_endian[4] = { 'n','d','n','d' };
static const uint8_t _matlab_modulus_endian[4] = { 'n','d','d','n' };
static const uint8_t _matlab_multiplicative_endian[4] = { 'n','d','d','n' };
static const uint8_t _matlab_unsigned_endian[4] = { 'n','d','d','n' };
static const uint8_t _matlab_divisor_endian[4] = { 'n','d','d','n' };
static const uint8_t _matlab_sign ac619d1d87
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